Relation Results

Summary

Name CDCA7
Full Name Cell division cycle-associated protein 7
Synonyms Protein JPO1 | JPO1
Primary ID Q9BWT1
Links - -
Type protein
Relations 2
Function Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insuff ...
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Type: Score: Layout: SPV 
0.20.343AKTCDCA7AKT1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKTdown-regulates img/direct_inhibition.png phosphorylation CDCA7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-199776 Thr163 SRRPRRRtFPGVASR Homo sapiens
pmid sentence
The prosurvival kinase akt phosphorylates cdca7 at threonine 163, promoting binding to 14-3-3, dissociation from myc, and sequestration to the cytoplasm. we have mapped the domains of interaction and have discovered that akt phosphorylates cdca7 near this contact region, leading to loss of its association with myc, binding to 14-3-3 proteins, and exclusion from the nucleus.
Publications: 1 Organism: Homo Sapiens
+ AKT1down-regulates img/direct_inhibition.png phosphorylation CDCA7 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-252533 Thr163 SRRPRRRtFPGVASR Homo sapiens
pmid sentence
The prosurvival kinase akt phosphorylates cdca7 at threonine 163, promoting binding to 14-3-3, dissociation from myc, and sequestration to the cytoplasm. we have mapped the domains of interaction and have discovered that akt phosphorylates cdca7 near this contact region, leading to loss of its association with myc, binding to 14-3-3 proteins, and exclusion from the nucleus.
Publications: 1 Organism: Homo Sapiens
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