+ |
BRIP1 | up-regulates quantity by stabilization
binding
|
BLM |
0.642 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259186 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
21240188 |
In this work, FANCJ and BLM were found to interact physically and functionally in human cells and co-localize to nuclear foci in response to replication stress. The cellular level of BLM is strongly dependent upon FANCJ, and BLM is degraded by a proteasome-mediated pathway when FANCJ is depleted. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RPA1 | up-regulates activity
binding
|
BRIP1 |
0.683 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259187 |
|
|
Homo sapiens |
|
pmid |
sentence |
17596542 |
Our data are consistent with a model in which FANCJ associates with RPA in a DNA damage-inducible manner and through the protein interaction RPA stimulates FANCJ helicase to better unwind duplex DNA substrates. These findings identify RPA as the first regulatory partner of FANCJ. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BRIP1 | form complex
binding
|
BRCA1-B complex |
0.661 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263219 |
|
|
|
|
pmid |
sentence |
25400280 |
Another BRCA1 complex, the BRCA1–B complex containing BRCA1/TopBP1 and BACH1 (also known and BRIP1/FANCJ) has been reported to play a role in HR and S‐phase cell cycle arrest. The exact role of this complex in HR remains unclear, although it is assumed that BACH1, a DNA helicase, contributes to end resection (possibly through its helicase activity) and RPA loading, whereas TopBP1 is required for ATR activation and subsequent S‐phase checkpoint activation |
|
Publications: |
1 |
+ |
BRIP1 | up-regulates activity
binding
|
BRCA1 |
0.787 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259185 |
|
|
Homo sapiens |
MCF-7 Cell, HCC-1937 Cell |
pmid |
sentence |
11301010 |
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. Moreover, BACH1 likely contributes to the DNA repair function of BRCA1 []. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |