Summary

Name PACSIN1
Full Name Protein kinase C and casein kinase substrate in neurons protein 1
Synonyms Syndapin-1 | KIAA1379
Primary ID Q9BY11
Links - -
Type protein
Relations 3
Function Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PACSIN1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PACSIN1 0.303
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PACSIN1 0.2
Publications: 1 Organism: In Vitro