| + |
PAK6 | up-regulates activity 
phosphorylation
|
GATA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278416 |
Ser161 |
SSLPVPNsAYGGPDF |
Homo sapiens |
|
| pmid |
sentence |
| 25726523 |
In addition, PAK5 knockdown also markedly reduced the association of GATA1 with HDAC3/4.|PAK5 phosphorylates the transcription factor GATA1 mainly at Ser161 and Ser 187, phosphorylated GATA1 recruits more HDAC3/4 to the promoter of E-cadherin and consequently suppresses the transcription of E-cadherin gene and promotes the EMT of breast cancer cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278415 |
Ser187 |
LNSAAYSsPKLRGTL |
Homo sapiens |
|
| pmid |
sentence |
| 25726523 |
In addition, PAK5 knockdown also markedly reduced the association of GATA1 with HDAC3/4.|PAK5 phosphorylates the transcription factor GATA1 mainly at Ser161 and Ser 187, phosphorylated GATA1 recruits more HDAC3/4 to the promoter of E-cadherin and consequently suppresses the transcription of E-cadherin gene and promotes the EMT of breast cancer cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
PAK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130979 |
Ser165 |
MPWPEPQsPRVLPNG |
Homo sapiens |
|
| pmid |
sentence |
| 15550393 |
The activation of pak6 by both p38 map kinase and mkk6 suggests that pak6 plays a role in the cellular response to stress-related signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates activity
phosphorylation
|
MDM2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276427 |
Ser186 |
RQRKRHKsDSISLSF |
Homo sapiens |
|
| pmid |
sentence |
| 23132866 |
We also showed that PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276428 |
Thr158 |
HLVSRPStSSRRRAI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23132866 |
We also showed that PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates activity
phosphorylation
|
RAF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278971 |
Ser338 |
RPRGQRDsSYYWEIE |
Homo sapiens |
|
| pmid |
sentence |
| 18465753 |
PAK5 phosphorylates Raf-1 on serine 338 and stimulates Raf-1 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates activity
phosphorylation
|
PACSIN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263021 |
Ser346 |
SQAGDRGsVSSYDRG |
in vitro |
|
| pmid |
sentence |
| 22371566 |
We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1 binding both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAK6 | down-regulates quantity by destabilization 
phosphorylation
|
AR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279247 |
Ser579 |
YGALTCGsCKVFFKR |
Homo sapiens |
|
| pmid |
sentence |
| 23132866 |
Furthermore, AR phosphorylation at Ser-578 by PAK6 promotes AR-E3 ligase murine double minute-2 (Mdm2) association, causing AR degradation upon androgen stimuli. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates quantity
phosphorylation
|
SLC25A5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279473 |
Thr107 |
LGGVDKRtQFWLYFA |
Homo sapiens |
|
| pmid |
sentence |
| 32194820 |
In the present study, it was demonstrated that ANT2 was phosphorylated by PAK6 at T107.|Moreover, PAK6 overexpression upregulated the protein expression of ANT2, while PAK6 knockdown led to opposing effects. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | down-regulates activity
phosphorylation
|
AIFM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278969 |
Thr281 |
GAEVKSRtTLFRKIG |
Homo sapiens |
|
| pmid |
sentence |
| 33867848 |
Furthermore, PAK5 phosphorylates AIF at Thr281 site to inhibit the formation of AIF/importin \u03b13 complex, leading to decrease AIF nuclear translocation.|These results suggested that PAK5 can inhibit AIF from entering the nucleus and prevent caspase- independent apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates activity
phosphorylation
|
LIMK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278970 |
Thr508 |
PDRKKRYtVVGNPYW |
Homo sapiens |
|
| pmid |
sentence |
| 25714010 |
PAK6 bound to LIMK1 and activated it via phosphorylation at Thr-508.|These data indicated that PAK6 directly phosphorylated LIMK1 at Thr-508. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates
phosphorylation
|
PAK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130975 |
Tyr566 |
KSLVGTPyWMAPEVI |
Homo sapiens |
|
| pmid |
sentence |
| 15550393 |
Moreover, pak6 was directly activated by mkk6, and mutation of tyrosine 566 in a consensus mkk6 site (threonine-proline-tyrosine, tpy) in the activation loop of the pak6 kinase domain prevented activation by mkk6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | down-regulates quantity
phosphorylation
|
CTNNB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279546 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24352566 |
Moreover, we find that \u03b2-catenin is also localized with PAK6 in cell-cell junctions and is a novel PAK6 substrate.|PAK6 binds to and phosphorylates beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK6 | up-regulates activity
phosphorylation
|
SYNJ1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263022 |
|
|
in vitro |
|
| pmid |
sentence |
| 22371566 |
We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1 binding both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
PAK6
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