3.0
Summary
| Name |  PAK6View Modifications |
| Full Name | Serine/threonine-protein kinase PAK 6 |
| Synonyms | PAK-5, p21-activated kinase 6, PAK-6 | PAK5 |
| Primary ID | Q9NQU5 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK14 | up-regulates 
phosphorylation
|
PAK6 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAK6 | up-regulates activity
phosphorylation
|
MDM2 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PAK6 | up-regulates activity
phosphorylation
|
PACSIN1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAP2K6 | up-regulates
phosphorylation
|
PAK6 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PAK6 | up-regulates activity
phosphorylation
|
SYNJ1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |