3.0
Summary
| Name |  PACSIN1View Modifications |
| Full Name | Protein kinase C and casein kinase substrate in neurons protein 1 |
| Synonyms | Syndapin-1 | KIAA1379 |
| Primary ID | Q9BY11 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PAK5 | up-regulates activity 
phosphorylation
|
PACSIN1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PAK6 | up-regulates activity
phosphorylation
|
PACSIN1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PAK4 | up-regulates activity
phosphorylation
|
PACSIN1 | 0.301 |
| Publications: | 1 | Organism: | In Vitro | |