| + |
MAPK1 | up-regulates quantity by stabilization
phosphorylation
|
DUSP16 |
0.808 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249389 |
Ser446 |
TNKLCQFsPVQELSE |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 15689616 |
Phosphorylation of Ser-446 determines stability of MKP-7.|We also determined that MKP-7 phosphorylated at Ser-446 has a longer half-life than unphosphorylated form of the wild type protein, as does a phospho-mimic mutant of MKP-7. These results indicate that activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DUSP16 | up-regulates
binding
|
MAPK8IP1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97173 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12524447 |
Here we report that jip-1 also binds the dual-specificity phosphatases mkp7 and m3/6 via a region independent of its jnk binding domain. when mkp7 is bound to jip-1 it reduces jnk activation leading to reduced phosphorylation of the jnk target c-jun |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP16 | down-regulates activity
dephosphorylation
|
MTOR |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277067 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25077541 |
MKP7 represses mTOR function.|These results suggest that MKP7 could directly dephosphorylate pmTOR and pPRAS40 and forming complexes with these two proteins ( xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP16 | down-regulates
dephosphorylation
|
MAPK14 |
0.805 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11359773 |
Mkp-7 binds to and inactivates p38 mapk and jnk/sapk, but not erk inhibited by dual specificity phosphatases, such as dusp1, dusp10, and dusp16(uniprot) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |