3.0
Summary
| Name |  NSD3View Modifications |
| Full Name | Histone-lysine N-methyltransferase NSD3 |
| Synonyms | Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1 | WHSC1L1 |
| Primary ID | Q9BZ95 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NSD3 | up-regulates activity 
methylation
|
IRF3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NSD3 | up-regulates activity
binding
|
MYC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NSD3 | up-regulates quantity by stabilization
binding
|
MYC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |