Summary

Name GLIS2
Full Name Zinc finger protein GLIS2
Synonyms GLI-similar 2, Neuronal Krueppel-like protein | NKL
Primary ID Q9BZE0
Links - -
Type protein
Relations 4
Function Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ CSNK1A1Lup-regulates img/indirect-activation.png GLIS2 0.2
Publications: 1 Organism: Homo Sapiens
+ PRKACAdown-regulates activity img/direct_inhibition.png phosphorylation GLIS2 0.287
Publications: 1 Organism: Homo Sapiens
+ SUFUdown-regulates img/direct_inhibition.png relocalization GLIS2 0.269
Publications: 1 Organism: Homo Sapiens
+ RAB23down-regulates img/indirect_inhibition.png GLIS2 0.2
Publications: 1 Organism: Homo Sapiens