4.0
Summary
| Name |  DPH1
|
| Full Name | 2- |
| Synonyms | Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, Ovarian cancer-associated gene 1 protein, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1 | DPH2L, DPH2L1, OVCA1 |
| Primary ID | Q9BZG8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DPH1 | form complex 
binding
|
2-(3-amino-3-carboxypropyl)histidine synthase complex | 0.78 |
| Publications: | 1 | Organism: | Homo Sapiens | |