3.0
Summary
| Name |  SETD5View Modifications |
| Full Name | Histone-lysine N-methyltransferase SETD5 |
| Synonyms | SET domain-containing protein 5 | KIAA1757 |
| Primary ID | Q9C0A6 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SETD5 | up-regulates activity 
methylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SETD5 | up-regulates activity
methylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SETD5 | up-regulates activity
methylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SETD5 | up-regulates activity
methylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | SETD5 | up-regulates 
|
Epigenetic_regulation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |