| + |
SETDB2 | up-regulates activity 
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263895 |
Lys 10 |
RTKQTARkSTGGKAP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20404330 |
Here, we have characterized a previously undescribed member of the histone H3K9 methyltransferase family named CLLD8 (or SETDB2 or KMT1F). This protein contributes to the trimethylation of both interspersed repetitive elements and centromere-associated repeats and participates in the recruitment of heterochromatin protein 1 to centromeres. Methylation of histone H3 at lysine 9 (H3K9) has emerged as an important player in the formation of heterochromatin, chromatin condensation, and transcriptional repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM4C | down-regulates activity 
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263867 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 29207681 |
As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.JMJD2C has been proved to be a demethylase for H3K9 methylation, in the manner of catalyzing the demethylation of H3K9me3/me2 (the known repressive markers of gene regulation), a histone mark found in heterochromatin associated with euchromatic transcriptional silencing and heterochromatin formation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263866 |
Lys37 |
APATGGVkKPHRYRP |
Homo sapiens |
|
| pmid |
sentence |
| 29207681 |
As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.JMJD2C has been proved to be a demethylase for H3K9 methylation, in the manner of catalyzing the demethylation of H3K9me3/me2 (the known repressive markers of gene regulation), a histone mark found in heterochromatin associated with euchromatic transcriptional silencing and heterochromatin formation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2A | down-regulates activity
acetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269596 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269604 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269613 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269621 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SAGA complex | down-regulates activity
acetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269630 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269638 |
Lys15 |
ARKSTGGkAPRKQLA |
Homo sapiens |
|
| pmid |
sentence |
| 34811519 |
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KDM3A | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276846 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 16603237 |
Using a biochemical assay coupled with chromatography, we have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF2 | down-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264520 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 21532585 |
PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. This modification leads to targeting of the PHF2–ARID5B complex to its target promoters, where it removes the repressive H3K9Me2 mark. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM3B | down-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266635 |
Lys10 |
RTKQTARkSTGGKAP |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 16603237 |
We have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. JHDM2A exhibits hormone-dependent recruitment to androgen-receptor target genes, resulting in H3K9 demethylation and transcriptional activation. Thus, our work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
JMJD1C | down-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265170 |
Lys10 |
RTKQTARkSTGGKAP |
Homo sapiens |
|
| pmid |
sentence |
| 32034158 |
We now determine that JMJD1C is recruited by USF-1 to various lipogenic genes for H3K9 demethylation to enhance chromatin accessibility in the fed state. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT7 | up-regulates activity
deacetylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275870 |
Lys19 |
TGGKAPRkQLATKVA |
|
|
| pmid |
sentence |
| 22722849 |
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.|Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275876 |
Lys37 |
APATGGVkKPHRYRP |
|
|
| pmid |
sentence |
| 30653310 |
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275882 |
Lys38 |
PATGGVKkPHRYRPG |
|
|
| pmid |
sentence |
| 30653310 |
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37. |
|
| Publications: |
3 |
| + |
SETD5 | up-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264621 |
Lys37 |
APATGGVkKPHRYRP |
in vitro |
|
| pmid |
sentence |
| 31515109 |
SETD5 Exhibits Intrinsic Methyltransferase Activity on H3K36. This assay showed that SETD5 has specific histone methyltransferase activity toward K36 but not for other residues such as K4 and K27 (Figure 8B). we revealed that SETD5 is endowed with H3K36 methyltransferase, which is necessary for RNA elongation and processing and, ultimately, correct gene transcription. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Set1-Ash2 HMT complex | down-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264483 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 12670868 |
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHF2 | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264517 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 21532585 |
PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. This modification leads to targeting of the PHF2–ARID5B complex to its target promoters, where it removes the repressive H3K9Me2 mark. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SETD1B | down-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265577 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 32546567 |
SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5B | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264303 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL1 complex | down-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268803 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL3 complex | down-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268812 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 34156443 |
MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. MLL3 and MLL4 form identical multi-protein complexes for modifying mono-methylation of histone H3 lysine 4 (H3K4) at enhancers, which together with the p300/CBP-mediated H3K27 acetylation can generate an active enhancer landscape for long-range target gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL2 complex | down-regulates activity
methylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268800 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 24680668 |
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5C | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264306 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri†and di†methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5D | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264309 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM1A | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264508 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 15620353 |
Here, we provide evidence that LSD1 (KIAA0601), a nuclear homolog of amine oxidases, functions as a histone demethylase and transcriptional corepressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KDM5A | up-regulates activity
demethylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264300 |
Lys5 |
kQTARKST |
Homo sapiens |
|
| pmid |
sentence |
| 30246379 |
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DOT1L |
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4.0
H3-4
- 
- 