3.0
Summary
| Name |  AICDAView Modifications |
| Full Name | Single-stranded DNA cytosine deaminase |
| Synonyms | Activation-induced cytidine deaminase, Cytidine aminohydrolase | AID |
| Primary ID | Q9GZX7 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA |
phosphorylation
|
AICDA | 0.329 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | FBXW11 | down-regulates quantity by destabilization 
binding
|
AICDA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 7-RBX1-Skp1 | down-regulates quantity by destabilization
ubiquitination
|
AICDA | 0.252 |
| Publications: | 1 | Organism: | Homo Sapiens | |