Summary

Name XRN2
Full Name 5'-3' exoribonuclease 2
Synonyms DHM1-like protein, DHP protein |
Primary ID Q9H0D6
Links - -
Type protein
Relations 1
Function Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation XRN2 0.251
Publications: 1 Organism: Homo Sapiens