3.0
Summary
| Name |  XRN2View Modifications |
| Full Name | 5'-3' exoribonuclease 2 |
| Synonyms | DHM1-like protein, DHP protein | |
| Primary ID | Q9H0D6 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK9 | up-regulates activity 
phosphorylation
|
XRN2 | 0.282 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CDK7 | up-regulates activity
phosphorylation
|
XRN2 | 0.25 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF8 | up-regulates activity
ubiquitination
|
XRN2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |