Summary

Name TOLLIP
Full Name Toll-interacting protein
Synonyms TOLIP_HUMAN |
Primary ID Q9H0E2
Links - -
Type protein
Relations 2
Pathways IL1 Receptor
Function Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding TOLLIP 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor
+ down-regulates activity img/direct_inhibition.png binding IRAK1 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor