Relation Results

Summary

Name IL1RAP
Full Name Interleukin-1 receptor accessory protein
Synonyms IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3 | C3orf13, IL1R3
Primary ID Q9NPH3
Links - -
Type protein
Relations 5
Pathways iCAF signaling in PDAC, IL1 Signaling , Macrophage: IL1 beta
Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound t ...
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Type: Score: Layout: SPV 
0.5060.8670.6360.7280.728IL1RL1IL1RAPIL1BTOLLIPIL1R1

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Relations
Regulator
Mechanism
target
score ℹ
+ IL1RL1up-regulates activity img/direct-activation.png binding IL1RAP 0.506
Identifier Residue Sequence Organism Cell Line
SIGNOR-277715 Homo sapiens
pmid sentence
The initial step in IL-33 signal transduction is ligand-induced conformational changes in IL-33R, which facilitate recruitment of interleukin-1 receptor accessory protein (IL-1RAP).
Publications: 1 Organism: Homo Sapiens
+ IL1Bup-regulates img/direct-activation.png binding IL1RAP 0.867
Identifier Residue Sequence Organism Cell Line
SIGNOR-61744 Homo sapiens
pmid sentence
The recently described il-1r accessory protein (il-1r acp) interacts with il-1beta and the il-1 type-ir (il-1ri).
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1RAPdown-regulates activity img/direct_inhibition.png binding TOLLIP 0.636
Identifier Residue Sequence Organism Cell Line
SIGNOR-251979 Homo sapiens HEK-293 Cell
pmid sentence
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1β treatment, Tollip is present in a complex with IRAK, and that recruitment of Tollip–IRAK complexes to the activated receptor complex occurs through association of Tollip with IL-1RAcP. Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (and IL-1Rs)
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1R1up-regulates activity img/direct-activation.png binding IL1RAP 0.728
Identifier Residue Sequence Organism Cell Line
SIGNOR-251981 Homo sapiens HEK-293 Cell
pmid sentence
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1β treatment, Tollip is present in a complex with IRAK, and that recruitment of Tollip–IRAK complexes to the activated receptor complex occurs through association of Tollip with IL-1RAcP. Co-recruited MyD88 then triggers IRAK autophosphorylation, which in turn leads to rapid dissociation of IRAK from Tollip (and IL-1Rs)
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1RAPup-regulates img/direct-activation.png binding IL1R1 0.728
Identifier Residue Sequence Organism Cell Line
SIGNOR-97396 Homo sapiens
pmid sentence
Here we report that the soluble form of the il-1 receptor accessory protein (acp) increases the affinity of binding of human il-1alpha and il-1beta to the soluble human type ii il-1 receptor by approximately 100-fold,
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
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