Summary

Name IL1RAP
Full Name Interleukin-1 receptor accessory protein
Synonyms IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3 | C3orf13, IL1R3
Primary ID Q9NPH3
Links - -
Type protein
Relations 5
Pathways iCAF signaling in PDAC, IL1 Signaling , Macrophage: IL1 beta
Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).

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Relations

Regulator Mechanism target score ℹ
+ IL1RAPup-regulates img/direct-activation.png binding IL1R1 0.718
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1RL1up-regulates activity img/direct-activation.png binding IL1RAP 0.516
Publications: 1 Organism: Homo Sapiens
+ IL1Bup-regulates img/direct-activation.png binding IL1RAP 0.862
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1RAPdown-regulates activity img/direct_inhibition.png binding TOLLIP 0.622
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ IL1R1up-regulates activity img/direct-activation.png binding IL1RAP 0.718
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling