+ |
BCL11A | down-regulates quantity by repression
transcriptional regulation
|
HBG2 |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251800 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
pmid |
sentence |
20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251775 |
|
|
Homo sapiens |
|
pmid |
sentence |
20712774 |
BCL11A maintains silencing of gamma-globin expression in adult erythroid cells and functions as a direct transcriptional regulator of the fetal to adult hemoglobin switch in humans. we found that BCL11A plays a central role in the evolutionarily divergent globin gene switches of mammals. As a factor critical for gamma-globin gene silencing, BCL11A should be considered as a therapeutic target to increase HbF in a directed manner in beta-thalassemia patients. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
BCL11A | down-regulates quantity by repression
transcriptional regulation
|
HBG1 |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269067 |
|
|
Homo sapiens |
Culture Condition:CD34+ Cell |
pmid |
sentence |
29606353 |
Our findings reveal that direct γ-globin gene promoter repression by BCL11A underlies hemoglobin switching. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
BCL11A | down-regulates quantity by repression
transcriptional regulation
|
HBG1 |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251802 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
pmid |
sentence |
20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251774 |
|
|
Homo sapiens |
|
pmid |
sentence |
20712774 |
BCL11A maintains silencing of gamma-globin expression in adult erythroid cells and functions as a direct transcriptional regulator of the fetal to adult hemoglobin switch in humans. we found that BCL11A plays a central role in the evolutionarily divergent globin gene switches of mammals. As a factor critical for gamma-globin gene silencing, BCL11A should be considered as a therapeutic target to increase HbF in a directed manner in beta-thalassemia patients. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
BCL11A | down-regulates quantity by repression
transcriptional regulation
|
HBG2 |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269066 |
|
|
Homo sapiens |
Culture Condition:CD34+ Cell |
pmid |
sentence |
29606353 |
Our findings reveal that direct γ-globin gene promoter repression by BCL11A underlies hemoglobin switching. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |