| + |
BCL11A | down-regulates quantity by repression 
transcriptional regulation
|
HBG2 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20712774 |
BCL11A maintains silencing of gamma-globin expression in adult erythroid cells and functions as a direct transcriptional regulator of the fetal to adult hemoglobin switch in humans. we found that BCL11A plays a central role in the evolutionarily divergent globin gene switches of mammals. As a factor critical for gamma-globin gene silencing, BCL11A should be considered as a therapeutic target to increase HbF in a directed manner in beta-thalassemia patients. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251800 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSF2 | up-regulates quantity by expression 
transcriptional regulation
|
HBG2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251776 |
|
|
Homo sapiens |
Erythroblast |
| pmid |
sentence |
| 2479426 |
Granulocyte-macrophage colony-stimulating factor reactivates fetal hemoglobin synthesis in erythroblast clones from normal adults. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2S1 | up-regulates quantity by expression
transcriptional regulation
|
HBG2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24714526 |
Reduction of globin inclusions and induction of ATF4 and HbF by the HRI-eIF2αP signaling provide strong bases for targeting this pathway for novel pharmaceutical therapy of hemoglobinopathy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL11A | down-regulates quantity by repression 
transcriptional regulation
|
HBG2 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269066 |
|
|
Homo sapiens |
Culture Condition:CD34+ Cell |
| pmid |
sentence |
| 29606353 |
Our findings reveal that direct γ-globin gene promoter repression by BCL11A underlies hemoglobin switching. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX6 | down-regulates quantity by repression
transcriptional regulation
|
HBG2 |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251808 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATA1 | down-regulates quantity by repression
transcriptional regulation
|
HBG2 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251804 |
|
|
Homo sapiens |
Erythroid Progenitor Cell |
| pmid |
sentence |
| 20395365 |
BCL11A and SOX6 co-occupy the human beta-globin cluster along with GATA1, and cooperate in silencing gamma-globin transcription in adult human erythroid progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2 | up-regulates quantity by expression
transcriptional regulation
|
HBG2 |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251840 |
|
|
Mus musculus |
Erythroleukemia Cell |
| pmid |
sentence |
| 16287851 |
NF-E2 is a transcription activator for the regulation of a number of erythroid- and megakaryocytic lineage-specific genes. Here we present evidence that the large subunit of mammalian NF-E2, p45, is sumoylated in vivo in human erythroid K562 cells. we demonstrated by stable transfection assay that only the wild-type p45, but not its mutant form p45 (K368R), could efficiently rescue β-globin gene expression in the p45-null, erythroid cell line CB3. These data together point to a model of mammalian β-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KLF11 | up-regulates quantity by expression
transcriptional regulation
|
HBG2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251827 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 10207080 |
Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTDSPL2 | up-regulates quantity by expression
transcriptional regulation
|
HBG2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251777 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 20932329 |
CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HBG2
- 
- 