Summary

Name CARD9
Full Name Caspase recruitment domain-containing protein 9
Synonyms hCARD9
Primary ID Q9H257
Links - -
Type protein
Relations 10
Function Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png polyubiquitination CARD9 0.529
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CARD9 0.352
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CARD9 0.352
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CARD9 0.404
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding BCL10 0.752
Publications: 1 Organism: Homo Sapiens