| + |
RNF146 | down-regulates quantity by destabilization 
ubiquitination
|
BLZF1 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263340 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21478859 |
Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated proteins. Using proteomics approaches, we have identified BLZF1 and CASC3 as further substrates targeted by tankyrase and RNF146 for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNKS | down-regulates quantity by destabilization
ADP-ribosylation
|
BLZF1 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263385 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21478859 |
Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated proteins. Using proteomics approaches, we have identified BLZF1 and CASC3 as further substrates targeted by tankyrase and RNF146 for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNKS2 | down-regulates quantity by destabilization
ADP-ribosylation
|
BLZF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263384 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21478859 |
Here, we identify RNF146, a RING-domain E3 ubiquitin ligase, as a positive regulator of Wnt signalling. RNF146 promotes Wnt signalling by mediating tankyrase-dependent degradation of axin. Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated proteins. Using proteomics approaches, we have identified BLZF1 and CASC3 as further substrates targeted by tankyrase and RNF146 for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BLZF1
- 
- 