Summary

Name TNKS
Full Name Poly [ADP-ribose] polymerase tankyrase-1
Synonyms TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, ARTD5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I | PARP5A, PARPL, TIN1, TINF1, TNKS1
Primary ID O95271
Links - -
Type protein
Relations 15
Inhibitors XAV939
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png GSK3B/Axin/APC 0.524
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding TARDBP 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation, ubiquitination AXIN2 0.765
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination TNKS 0.714
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RNF146 0.714
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.796
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation BLZF1 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation, ubiquitination AXIN1 0.767
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition TNKS 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition TNKS 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation CASC3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation PSMF1 0.475
Publications: 1 Organism: Homo Sapiens