Summary

Name PARL
Full Name Presenilins-associated rhomboid-like protein, mitochondrial
Synonyms Mitochondrial intramembrane cleaving protease PARL | PSARL
Primary ID Q9H300
Links - -
Type protein
Relations 1
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872).

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Relations

Regulator Mechanism target score ℹ
+ PARLdown-regulates quantity by destabilization img/direct_inhibition.png cleavage PINK1 0.64
Publications: 1 Organism: Homo Sapiens