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Summary
| Name |  PARL
|
| Full Name | Presenilins-associated rhomboid-like protein, mitochondrial |
| Synonyms | Mitochondrial intramembrane cleaving protease PARL | PSARL |
| Primary ID | Q9H300 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (PubMed:14732705, PubMed:17116872). |
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phosphorylation
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