+ |
CUL3 | up-regulates activity
binding
|
KCTD10 |
0.508 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264234 |
|
|
Homo sapiens |
|
pmid |
sentence |
19782033 |
BACURDs form ubiquitin ligase complexes, which selectively ubiquitinate RhoA, with Cul3. Our studies reveal a previously unknown mechanism for controlling RhoA degradation and regulating RhoA function in various biological contexts, which involves a Cul3/BACURD ubiquitin ligase complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KCTD10 | down-regulates quantity by destabilization
binding
|
CEP97 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272923 |
|
|
Homo sapiens |
HTERT-RPE1 Cell |
pmid |
sentence |
30404837 |
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. we identified the cullin-3-RBX1-KCTD10 complex as the E3 ligase that mediates CEP97 degradation and removal from the mother centriole. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KCTD10 | down-regulates quantity
binding
|
RHOA |
0.273 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264237 |
|
|
Homo sapiens |
|
pmid |
sentence |
19782033 |
BACURDs form ubiquitin ligase complexes, which selectively ubiquitinate RhoA, with Cul3. Our studies reveal a previously unknown mechanism for controlling RhoA degradation and regulating RhoA function in various biological contexts, which involves a Cul3/BACURD ubiquitin ligase complex. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KCTD10 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.508 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272924 |
|
|
Homo sapiens |
HTERT-RPE1 Cell |
pmid |
sentence |
30404837 |
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. we identified the cullin-3-RBX1-KCTD10 complex as the E3 ligase that mediates CEP97 degradation and removal from the mother centriole. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |