| + |
PRKCA | down-regulates activity 
phosphorylation
|
CDC42EP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263160 |
Ser18 |
SVHSKRRsRADLTAE |
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 25086031 |
Cdc42 effector protein-4 (CEP4) was recently identified by our laboratory to be a substrate of multiple PKC isoforms in non-transformed MCF-10A human breast cells. MS/MS analysis verified that Ser(18) and Ser(80) were directly phosphorylated by PKCα in vitro. Phosphorylation of CEP4 severely diminished its affinity for Cdc42 while promoting Rac activation and formation of filopodia (microspikes). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263161 |
Ser80 |
SSKRSLLsRKFRGSK |
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 25086031 |
Cdc42 effector protein-4 (CEP4) was recently identified by our laboratory to be a substrate of multiple PKC isoforms in non-transformed MCF-10A human breast cells. MS/MS analysis verified that Ser(18) and Ser(80) were directly phosphorylated by PKCα in vitro. Phosphorylation of CEP4 severely diminished its affinity for Cdc42 while promoting Rac activation and formation of filopodia (microspikes). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
CDC42EP4
- 
- 