Relation Results

Summary

Name DOK1
Full Name Docking protein 1
Synonyms Downstream of tyrosine kinase 1, p62(dok), pp62
Primary ID Q99704
Links - -
Type protein
Relations 41
Pathways Integrin Signaling
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling com ...
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Type: Score: Layout: SPV 
0.2540.550.480.2990.5890.20.3380.2990.3180.3180.3180.20.2970.2990.2990.2990.3270.3180.6020.2970.2990.20.3180.3270.420.3180.3180.3180.3180.3180.20.20.3380.3180.20.3380.327IKBKBDOK1INSRPTK6AX/b2 integrinLCKAv/b8 integrinAv/b3 integrinITGB2A6/b1 integrinA4/b1 integrinA1/b1 integrinITGB8Av/b5 integrinAM/b2 integrinAv/b2 integrinAD/b2 integrinA4/b7 integrinITGB1RETITGB5AL/b2 integrinITGB6A10/b1 integrinAE/b7 integrinSRMSA11/b1 integrinA9/b1 integrinA2/b1 integrinA5/b1 integrinA8/b1 integrinAv/b6 integrinITGB4ITGB3A3/b1 integrinA6/b4 integrinAIIB/b3 integrinITGB7

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ IKBKBup-regulates img/direct-activation.png phosphorylation DOK1 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-131447 Ser439 EPGTATGsGIKSHNS Homo sapiens
pmid sentence
Ikkbeta phosphorylates dok1 s(439)s(443) and s(446)s(450) after tnf-alpha, il-1, or gamma-radiation. mutant dok1 a(439), a(443), a(446), and a(450) differed from wild-type dok1 in not inhibiting platelet-derived growth factor-induced extracellular signal-regulated kinase 1/2 phosphorylation or cell growth. Mutant dok1 a(439), a(443), a(446), and a(450) also did not promote cell motility whereas wild-type dok1 promoted cell motility.
Identifier Residue Sequence Organism Cell Line
SIGNOR-131451 Ser443 ATGSGIKsHNSALYS Homo sapiens
pmid sentence
Ikkbeta phosphorylates dok1 s(439)s(443) and s(446)s(450) after tnf-alpha, il-1, or gamma-radiation. mutant dok1 a(439), a(443), a(446), and a(450) differed from wild-type dok1 in not inhibiting platelet-derived growth factor-induced extracellular signal-regulated kinase 1/2 phosphorylation or cell growth. Mutant dok1 a(439), a(443), a(446), and a(450) also did not promote cell motility whereas wild-type dok1 promoted cell motility.
Identifier Residue Sequence Organism Cell Line
SIGNOR-131455 Ser446 SGIKSHNsALYSQVQ Homo sapiens
pmid sentence
Ikkbeta phosphorylates dok1 s(439)s(443) and s(446)s(450) after tnf-alpha, il-1, or gamma-radiation. mutant dok1 a(439), a(443), a(446), and a(450) differed from wild-type dok1 in not inhibiting platelet-derived growth factor-induced extracellular signal-regulated kinase 1/2 phosphorylation or cell growth. Mutant dok1 a(439), a(443), a(446), and a(450) also did not promote cell motility whereas wild-type dok1 promoted cell motility.
Identifier Residue Sequence Organism Cell Line
SIGNOR-131556 Ser450 SHNSALYsQVQKSGA Homo sapiens
pmid sentence
Ikkbeta phosphorylates dok1 s(439)s(443) and s(446)s(450) after tnf-alpha, il-1, or gamma-radiation. mutant dok1 a(439), a(443), a(446), and a(450) differed from wild-type dok1 in not inhibiting platelet-derived growth factor-induced extracellular signal-regulated kinase 1/2 phosphorylation or cell growth. Mutant dok1 a(439), a(443), a(446), and a(450) also did not promote cell motility whereas wild-type dok1 promoted cell motility.
Publications: 4 Organism: Homo Sapiens
+ INSRup-regulates activity img/direct-activation.png phosphorylation DOK1 0.55
Identifier Residue Sequence Organism Cell Line
SIGNOR-251307 Tyr362 DPKEDPIyDEPEGLA Cricetulus griseus CHO Cell
pmid sentence
Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398. p62(dok) is a direct substrate for the IR tyrosine kinase and that phosphorylation at Tyr(362) and Tyr(398) plays an essential role for p62(dok) to interact with its effectors and negatively regulate the insulin signaling pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251308 Tyr398 ARVKEEGyELPYNPA Cricetulus griseus CHO Cell
pmid sentence
Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398. p62(dok) is a direct substrate for the IR tyrosine kinase and that phosphorylation at Tyr(362) and Tyr(398) plays an essential role for p62(dok) to interact with its effectors and negatively regulate the insulin signaling pathway.
Publications: 2 Organism: Cricetulus Griseus
+ PTK6down-regulates activity img/direct_inhibition.png phosphorylation DOK1 0.48
Identifier Residue Sequence Organism Cell Line
SIGNOR-278301 Tyr362 DPKEDPIyDEPEGLA Homo sapiens
pmid sentence
BRK downregulates Dok1 via proteasomal degradation.|BRK phosphorylates Dok1 at tyrosine 362.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AX/b2 integrin 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257683 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ LCKup-regulates activity img/direct-activation.png phosphorylation DOK1 0.589
Identifier Residue Sequence Organism Cell Line
SIGNOR-251373 Homo sapiens
pmid sentence
Phosphorylation of p56 dok and p62 dok is increased following CD2 stimulation and requires Lck. Phosphorylation of Dok proteins by Lck might provide a mechanism by which SH2-containing proteins can be recruited and co-localized with their substrates.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding Av/b8 integrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257699 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding Av/b3 integrin 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-257688 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB2 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257680 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A6/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257675 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding A4/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257673 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A1/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257670 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB8 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257698 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding Av/b5 integrin 0.297
Identifier Residue Sequence Organism Cell Line
SIGNOR-257692 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AM/b2 integrin 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257682 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding Av/b2 integrin 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257684 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AD/b2 integrin 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257685 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A4/b7 integrin 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-257697 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB1 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257669 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ RETup-regulates img/direct-activation.png binding DOK1 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-90158 Homo sapiens
pmid sentence
Dok proteins directly associate with tyrosine 1062 of ret and could be its substrates. Phosphorylation of dok1 is necessary for interaction with ras-gap in vitro and in vivo. Dok1 is a negative regulator for the ras/erk signaling pathway activated by ret.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB5 0.297
Identifier Residue Sequence Organism Cell Line
SIGNOR-257691 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AL/b2 integrin 0.299
Identifier Residue Sequence Organism Cell Line
SIGNOR-257681 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257693 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A10/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257678 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding AE/b7 integrin 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-257696 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ SRMS img/unknown.png phosphorylation DOK1 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-264569 Homo sapiens HEK-293 Cell
pmid sentence
These data indicate that ectopically‐expressed GFP‐SRMS interacts with and mediates the phosphorylation of overexpressed GFP‐Dok1.
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A11/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257679 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A9/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257677 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A2/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257671 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A5/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257674 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A8/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257676 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding Av/b6 integrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257694 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257689 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB3 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-257687 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding A3/b1 integrin 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-257672 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding A6/b4 integrin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-257690 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ DOK1down-regulates activity img/direct_inhibition.png binding AIIB/b3 integrin 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-257686 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB7 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-257695 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
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