Summary

Name DOK1
Full Name Docking protein 1
Synonyms Downstream of tyrosine kinase 1, p62(dok), pp62
Primary ID Q99704
Links - -
Type protein
Relations 39
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DOK1 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DOK1 0.14
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png binding AL/b2 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AM/b2 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Av/b2 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AX/b2 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB7 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB8 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A2/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A3/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A4/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A10/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB4 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A4/b7 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Av/b3 integrin 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB3 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DOK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DOK1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A1/b1 integrin 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A11/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AD/b2 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A6/b4 integrin 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB5 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Av/b5 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB6 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Av/b6 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AE/b7 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A5/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Av/b8 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A6/b1 integrin 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A8/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding A9/b1 integrin 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ITGB1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AIIB/b3 integrin 0.14
Publications: 1 Organism: Homo Sapiens