+ |
PRKDC | up-regulates activity
phosphorylation
|
GOLPH3 |
0.323 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253557 |
Thr143 |
ALKHVKEtQPPETVQ |
in vitro |
HeLa Cell |
pmid |
sentence |
24485452 |
In response to DNA damage, DNA-PK phosphorylates GOLPH3, resulting in increased interaction with MYO18A, which applies a tensile force to the Golgi. Interference with the Golgi DNA damage response by depletion of DNA-PK, GOLPH3, or MYO18A reduces survival after DNA damage, whereas overexpression of GOLPH3, as is observed frequently in human cancers, confers resistance to killing by DNA-damaging agents |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253558 |
Thr148 |
KETQPPEtVQNWIEL |
in vitro |
HeLa Cell |
pmid |
sentence |
24485452 |
In response to DNA damage, DNA-PK phosphorylates GOLPH3, resulting in increased interaction with MYO18A, which applies a tensile force to the Golgi. Interference with the Golgi DNA damage response by depletion of DNA-PK, GOLPH3, or MYO18A reduces survival after DNA damage, whereas overexpression of GOLPH3, as is observed frequently in human cancers, confers resistance to killing by DNA-damaging agents |
|
Publications: |
2 |
Organism: |
In Vitro |
+ |
GOLPH3 | up-regulates activity
|
MTOR |
0.338 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253554 |
|
|
Homo sapiens |
A-549 Cell, 1205-Lu Cell |
pmid |
sentence |
19553991 |
Mechanistically, GOLPH3 regulates cell size, enhances growth factor-induced mTOR signaling in human cancer cells and alters response to mTOR inhibitor in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GOLPH3 | up-regulates activity
|
mTORC1 |
0.3 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253555 |
|
|
Homo sapiens |
|
pmid |
sentence |
19553991 |
Mechanistically, GOLPH3 regulates cell size, enhances growth factor-induced mTOR signaling in human cancer cells and alters response to mTOR inhibitor in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GOLPH3 | up-regulates activity
|
mTORC2 |
0.297 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253556 |
|
|
Homo sapiens |
A-549 Cell, 1205-Lu Cell |
pmid |
sentence |
19553991 |
Mechanistically, GOLPH3 regulates cell size, enhances growth factor-induced mTOR signaling in human cancer cells and alters response to mTOR inhibitor in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |