Summary

Name OSBPL3
Full Name Oxysterol-binding protein-related protein 3
Synonyms ORP-3, OSBP-related protein 3 | KIAA0704, ORP3, OSBP3
Primary ID Q9H4L5
Links - -
Type protein
Relations 1
Function Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).

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Relations

Regulator Mechanism target score ℹ
+ OSBPL3down-regulates activity img/direct_inhibition.png binding RRAS 0.416
Publications: 1 Organism: Homo Sapiens