| + |
ERK1/2 | up-regulates activity 
phosphorylation
|
RRAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277220 |
Ser186 |
S-->L |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 27086924 |
In this study, we report that TC21 and R-Ras are phosphorylated on a conserved serine, Ser186 and Ser201, respectively, in intact cells. This residue is located in the C-terminal hypervariable region of the proteins and is not conserved in M-Ras. We show that the MAP kinases ERK1/2 phosphorylate TC21 and R-Ras on this C-terminal serine residue both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277219 |
Ser201 |
QEQELPPsPPSAPRK |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 27086924 |
In this study, we report that TC21 and R-Ras are phosphorylated on a conserved serine, Ser186 and Ser201, respectively, in intact cells. This residue is located in the C-terminal hypervariable region of the proteins and is not conserved in M-Ras. We show that the MAP kinases ERK1/2 phosphorylate TC21 and R-Ras on this C-terminal serine residue both in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SRC | down-regulates activity 
phosphorylation
|
RRAS |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111189 |
Tyr66 |
DPTIEDSyTKICSVD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11682467 |
The small gtpase, r-ras, affects cell adhesion by maintaining integrin activity. Activated src oncogene phosphorylates r-ras and suppresses integrin activity. the src phosphorylation site in r-ras was tyrosine 66 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPHB2 | down-regulates activity
phosphorylation
|
RRAS |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251125 |
Tyr66 |
DPTIEDSyTKICSVD |
Homo sapiens |
|
| pmid |
sentence |
| 10570155 |
Tyrosine 66 of R-Ras is phosphorylated by EphB2|. R-Ras, a small intracellular GTPase, regulates the binding of integrins to their ligands outside the cell. |Cells in which EphB2 is activated become poorly adherent to substrates coated with integrin ligands, and a tyrosine residue in the R-Ras effector domain is phosphorylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OSBPL3 | down-regulates activity
binding
|
RRAS |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277221 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18270267 |
We show that ORP3 interacts with R-Ras, a small GTPase regulating cell adhesion, spreading and migration. Gene silencing of ORP3 in HEK293 cells results in altered organization of the actin cytoskeleton, impaired cell-cell adhesion, enhanced cell spreading and an increase of beta1 integrin activity--effects similar to those of constitutively active R-Ras(38V). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RRAS
- 
- 