Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256155 |
|
|
Mus musculus |
Myeloid Leukemia Cell Line |
pmid |
sentence |
27458164 |
We screened a panel of SH2 domain-containing proteins and identified SLAP2 as a potent interacting partner of FLT3. We demonstrated that interaction occurs when FLT3 is activated, and also, an intact SH2 domain of SLAP2 is required for binding. Expression of SLAP2 blocked FLT3 downstream signaling cascades including AKT, ERK, p38 and STAT5. |
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