Summary

Name FLT3
Full Name Receptor-type tyrosine-protein kinase FLT3
Synonyms FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1 | CD135, FLK2, STK1
Primary ID P36888
Links - -
Type protein
Relations 115
Pathways Acute Myeloid Leukemia, AML1-ETO in AML, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
Inhibitors [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone; JNJ-28312141 free base; sorafenib tosylate; dovitinib; bis(lactic acid); midostaurin; regorafenib; sunitinib; CHIR-124; quizartinib; LSM-1231; linifanib; Ast-487; TG101209; sorafenib; cabozantinib; ponatinib; 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone; 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one; MK-2461; tandutinib; anthra[1,9-cd]pyrazol-6(2H)-one
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation IDH2 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, NPM1_new
+ down-regulates activity img/direct_inhibition.png phosphorylation SIRT3 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.445
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation IDH1 0.424
Publications: 2 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, NPM1_new
+ up-regulates activity img/direct-activation.png phosphorylation ACAT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLT3 0.2
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ up-regulates activity img/direct-activation.png phosphorylation FLT3 0.2
Publications: 4 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ up-regulates quantity img/direct-activation.png phosphorylation FLT3 0.419
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT5A 0.603
Publications: 2 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML
+ img/unknown.png phosphorylation FLT3 0.2
Publications: 4 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ up-regulates activity img/direct-activation.png phosphorylation FLT3 0.408
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.29
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ID1 0.263
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, miRNA in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.281
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PTPN11 0.525
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD signaling, NPM1_new
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPA 0.631
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 2 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png ERK1/2 0.292
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ down-regulates activity img/indirect_inhibition.png ZBTB16 0.314
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation FLT3 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation USP22 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by stabilization img/indirect-activation.png post transcriptional regulation SIRT1 0.349
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2L11 0.322
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png PI3K 0.556
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, WNT/FLT3
+ up-regulates img/direct-activation.png binding FLT3 0.885
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 2 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation XRCC5 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png AKT 0.431
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FZD4 0.2
Publications: 2 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CEBPB 0.296
Publications: 1
Pathways:Acute Myeloid Leukemia, miRNA in AML, FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 2 Organism: In Vitro
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation PTPN6 0.368
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding FLT3 0.248
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 2 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS2 0.43
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png AKT1 0.431
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/indirect_inhibition.png PTPRJ 0.49
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/indirect-activation.png RUNX1 0.361
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, miRNA in AML, NPM1_new
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png HK2 0.258
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FLT3 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RAC1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, WNT/FLT3
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.29
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM2 0.336
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GRB10 0.365
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SPI1 0.62
Publications: 2 Organism: , Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, miRNA in AML, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.409
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling, WNT/FLT3
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PARP1 0.25
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CISH 0.299
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation FLT3 0.49
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM1 0.419
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png Hexokinase 0.264
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Skeletal_muscle_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2L1 0.335
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ down-regulates activity img/direct_inhibition.png binding FLT3 0.437
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ down-regulates activity img/direct_inhibition.png ubiquitination FLT3 0.327
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation miR-155 0.4
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.604
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates quantity by expression img/indirect-activation.png MYC 0.363
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ down-regulates activity img/indirect_inhibition.png FOXO3 0.309
Publications: 1 Organism: Mus Musculus
Pathways:FLT3 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RAD51 0.251
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png PIK3R1 0.566
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.287
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png Glycolysis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTPN6 0.368
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.431
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3
+ down-regulates activity img/indirect_inhibition.png relocalization NCOR2 0.257
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML