+ |
DCTPP1 | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.335 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261178 |
|
|
Homo sapiens |
BGC-823 Cell |
pmid |
sentence |
27612427 |
DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically; Moreover, low expression of DCTPP1 led to the increase in intracellular 5-methyl-dCTP, which was strongly associated with the promoter hyper-methylation, leading to the subsequent low-expression of MDR1 and the increased intracellular accumulation of 5-FU in DCTPP1-knockdown BGC-823 cells. These results provide new insights into the roles of DCTPP1 as a chemosensitizer in clinical application. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DCTPP1 | up-regulates quantity by expression
chemical modification
|
dCMP 3'-end residue |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261333 |
|
|
Rattus norvegicus |
|
pmid |
sentence |
31377845 |
Our data indicate that DCTPP1 is crucially involved in the provision of dCMP for thymidylate biosynthesis, introducing a new player in the regulation of pyrimidine dNTP levels and the maintenance of genomic integrity |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
DCTPP1 | up-regulates
|
Autophagy |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261177 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
pmid |
sentence |
29874556 |
Autophagy Induced by Overexpression of DCTPP1 Promotes Tumor Progression and Predicts Poor Clinical Outcome in Prostate Cancer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
6-(3,4-Dimethoxyphenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | down-regulates activity
chemical inhibition
|
DCTPP1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261113 |
|
|
Homo sapiens |
|
pmid |
sentence |
28145708 |
Here we report on thediscovery of a series of 3,6-disubstituted triazolothiadiazolesas potent dCTPase inhibitors. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |