Summary

Name DCTPP1
Full Name dCTP pyrophosphatase 1
Synonyms Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated gene A protein | XTP3TPA
Primary ID Q9H773
Links - -
Type protein
Relations 4
Inhibitors 6-(3,4-Dimethoxyphenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Function Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.335
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png chemical modification dCMP 3'-end residue 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png Autophagy 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition DCTPP1 0.8
Publications: 1 Organism: Homo Sapiens