| + |
LRRK2 | up-regulates 
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-237005 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22012985 |
We report that LRRK2 activates a calcium-dependent protein kinase kinase-² (CaMKK-²)/adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway which is followed by a persistent increase in autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | down-regulates 
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
Historically, it was known that autophagy was switched off when mTORC1 was active and that inhibition of mTORC1 was a potent autophagy inducer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
TM9SF4 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266704 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29125601 |
In the present study, we report a novel autophagy-related protein TM9SF4, which plays a functional role in the induction phase of autophagic process. Overexpression of TM9SF4 promoted autophagic flux in HEK293 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOD2 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252403 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19898471 |
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for inducing autophagy in response to bacterial infection remain unknown. Here we demonstrated that the intracellular sensors Nod1 and Nod2 are critical for the autophagic response to invasive bacteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCTPP1 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261177 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 29874556 |
Autophagy Induced by Overexpression of DCTPP1 Promotes Tumor Progression and Predicts Poor Clinical Outcome in Prostate Cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates activity
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261952 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22931788 |
Forkhead box O (FOXO) transcriptional protein family members, including FOXO1 and FOXO3, are involved in the modulation of autophagy. However, whether there is redundancy between FOXO1 and FOXO3 in the ability to induce autophagy remains unclear. In this study, we showed that FOXO3 induced a transcription-dependent autophagy, and FOXO1 was required for this process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
WDFY3 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22653340 |
ALFY is a large, scaffolding, multidomain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophagy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Autophagy | up-regulates
|
Protein_aggregates |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262269 |
|
|
|
|
| pmid |
sentence |
| 32218723 |
In many neurodegenerative conditions protein aggregation may occurs without specific GOF mutations in genes encoding aggregate-prone proteins. In these conditions protein aggregation is associated to the decline of cellular degradative functions, specifically of the autophagy-lysosomal pathway (ALP) (Figure 1). |
|
| Publications: |
1 |
| + |
Vps34 Complex II | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260326 |
|
|
|
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
| Pathways: | Autophagy |
| + |
NOD1 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252404 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19898471 |
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for inducing autophagy in response to bacterial infection remain unknown. Here we demonstrated that the intracellular sensors Nod1 and Nod2 are critical for the autophagic response to invasive bacteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ULK1/Atg13/Fip200 | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209907 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23863160 |
In mammals, two protein complexes, namely the ULK1/Atg13/FIP200 (200kDa focal adhesion kinase family-interacting protein) complex and the Beclin/Vps34 complex, function jointly to produce the phagophore membrane, the initial phase of autophagosome formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Autophagy |
| + |
Vps34 Complex I | up-regulates
|
Autophagy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260325 |
|
|
|
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
| Pathways: | Autophagy |
3.0
Autophagy