Summary

Name TLE6
Full Name Transducin-like enhancer protein 6
Synonyms TLE6_HUMAN |
Primary ID Q9H808
Links - -
Type protein
Relations 1
Function Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TLE6 0.2
Publications: 1 Organism: Homo Sapiens