Summary

Name PELI2
Full Name E3 ubiquitin-protein ligase pellino homolog 2
Synonyms Pellino-2
Primary ID Q9HAT8
Links - -
Type protein
Relations 4
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

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Relations

Regulator Mechanism target score ℹ
+ IRAK1up-regulates activity img/direct-activation.png phosphorylation PELI2 0.78
Publications: 1 Organism: Homo Sapiens
+ PELI2up-regulates activity img/direct-activation.png ubiquitination NLRP3 0.2
Publications: 1 Organism: Homo Sapiens
+ PELI2up-regulates img/direct-activation.png ubiquitination IRAK1 0.78
Publications: 1 Organism: Homo Sapiens
+ IRAK4up-regulates img/direct-activation.png phosphorylation PELI2 0.637
Publications: 1 Organism: Homo Sapiens