Summary

Name NLRP3
Full Name NACHT, LRR and PYD domains-containing protein 3
Synonyms Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1 | C1orf7, CIAS1, NALP3, PYPAF1
Primary ID Q96P20
Links - -
Type protein
Relations 10
Function As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ Cullin 1-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NLRP3 0.2
Publications: 1 Organism: Homo Sapiens
+ MAPK8up-regulates activity img/direct-activation.png phosphorylation NLRP3 0.378
Publications: 1 Organism: In Vitro
+ PKAdown-regulates activity img/direct_inhibition.png phosphorylation NLRP3 0.2
Publications: 1 Organism: In Vitro
+ PAK1up-regulates activity img/direct-activation.png phosphorylation NLRP3 0.2
Publications: 1 Organism: Homo Sapiens
+ FBXL2down-regulates quantity by destabilization img/direct_inhibition.png binding NLRP3 0.357
Publications: 1 Organism: Homo Sapiens
+ NLRP3form complex img/form-complex.png binding NLRP3 inflammasome 0.738
Publications: 1
+ PTPN22up-regulates activity img/direct-activation.png dephosphorylation NLRP3 0.364
Publications: 1 Organism: Homo Sapiens
+ TLRsup-regulates quantity by expression img/indirect-activation.png NLRP3 0.2
Publications: 1
+ KCNJ8down-regulates activity img/direct_inhibition.png binding NLRP3 0.2
Publications: 1 Organism: Homo Sapiens
+ ROSup-regulates activity img/indirect-activation.png NLRP3 0.7
Publications: 1