3.0
Summary
| Name |  PELI2
|
| Full Name | E3 ubiquitin-protein ligase pellino homolog 2 |
| Synonyms | Pellino-2 |
| Primary ID | Q9HAT8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. |
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ubiquitination