3.0
Summary
| Name |  SPC25
|
| Full Name | Kinetochore protein Spc25 |
| Synonyms | hSpc25 | SPBC25 |
| Primary ID | Q9HBM1 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SPC25 | form complex 
binding
|
Ndc80 complex | 0.973 |
| Publications: | 1 | |||