| + |
SUGT1 | up-regulates activity 
relocalization
|
Ndc80 complex |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265224 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22869522 |
Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during mitosis|This phosphorylation event enhances the association of the Hsp90-Sgt1 chaperone with the MIS12 complex to stabilize this complex at the kinetochores and thus coordinates the recruitment of the NDC80 complex to form efficient microtubule-binding sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ndc80 complex | form complex 
binding
|
KMN network |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265218 |
|
|
|
|
| pmid |
sentence |
| 18007590 |
The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, |
|
| Publications: |
1 |
| + |
SPC25 | form complex
binding
|
Ndc80 complex |
0.973 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265186 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits |
|
| Publications: |
1 |
| + |
SPC24 | form complex
binding
|
Ndc80 complex |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265185 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits |
|
| Publications: |
1 |
| + |
NUF2 | form complex
binding
|
Ndc80 complex |
0.973 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265187 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits |
|
| Publications: |
1 |
| + |
SKA complex | up-regulates activity
relocalization
|
Ndc80 complex |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265225 |
|
|
in vitro |
|
| pmid |
sentence |
| 22483620 |
The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is composed of three subunits that function together to establish stable kinetochore-microtubule interactions in concert with the Ndc80 network. |We discuss how this symmetric architecture might complement and stabilize the Ndc80-microtubule attachments |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NDC80 | form complex
binding
|
Ndc80 complex |
0.965 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265188 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits |
|
| Publications: |
1 |
3.0
Ndc80 complex
CPX-550