Summary

Name MOV10
Full Name Helicase MOV-10
Synonyms Armitage homolog, Moloney leukemia virus 10 protein | KIAA1631
Primary ID Q9HCE1
Links - -
Type protein
Relations 3
Function 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development

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Relations

Regulator Mechanism target score ℹ
+ MOV10up-regulates activity img/direct-activation.png binding UPF1 0.518
Publications: 1 Organism: Homo Sapiens
+ MOV10up-regulates activity img/direct-activation.png binding IKBKE 0.2
Publications: 1 Organism: Homo Sapiens
+ Interferon-type-Iup-regulates quantity by expression img/indirect-activation.png transcriptional regulation MOV10 0.2
Publications: 1 Organism: Homo Sapiens