Relation Results

Name	TRIM39
Full Name	E3 ubiquitin-protein ligase TRIM39
Synonyms	RING finger protein 23, RING-type E3 ubiquitin transferase TRIM39, Testis-abundant finger protein, Tripartite motif-containing protein 39 \| RNF23, TFP
Primary ID	Q9HCM9
Links	- -
Type	protein
Relations	3
Function	E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).