Summary

Name GOPC
Full Name Golgi-associated PDZ and coiled-coil motif-containing protein
Synonyms CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST | CAL, FIG
Primary ID Q9HD26
Links - -
Type protein
Relations 4
Function Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.

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Relations

Regulator Mechanism target score ℹ
+ GOPCdown-regulates img/direct_inhibition.png relocalization ADRB1 0.349
Publications: 1 Organism: Homo Sapiens
+ GOPCup-regulates img/direct-activation.png binding BECN1 0.539
Publications: 1 Organism: Homo Sapiens
+ GOLGA3up-regulates activity img/direct-activation.png binding GOPC 0.494
Publications: 1 Organism: Homo Sapiens
+ GOPCdown-regulates img/direct_inhibition.png binding CFTR 0.711
Publications: 1 Organism: Homo Sapiens