Summary

Name SLCO1B3
Full Name Solute carrier organic anion transporter family member 1B3
Synonyms Liver-specific organic anion transporter 2, LST-2, Organic anion transporter 8, Organic anion-transporting polypeptide 8, OATP-8, Solute carrier family 21 member 8 | LST2, OATP1B3, OATP8, SLC21A8
Primary ID Q9NPD5
Links - -
Type protein
Relations 5
Function Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

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Relations

Regulator Mechanism target score ℹ
+ HNF1Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation SLCO1B3 0.254
Publications: 1
+ FOXA2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SLCO1B3 0.2
Publications: 1 Organism: Homo Sapiens
+ STAT5Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation SLCO1B3 0.2
Publications: 1
+ RARAup-regulates quantity by expression img/direct-activation.png transcriptional regulation SLCO1B3 0.2
Publications: 1
+ CEBPGup-regulates quantity by expression img/direct-activation.png transcriptional regulation SLCO1B3 0.2
Publications: 1