Summary

Name RARA
Full Name Retinoic acid receptor alpha
Synonyms RAR-alpha, Nuclear receptor subfamily 1 group B member 1 | NR1B1
Primary ID P10276
Links - -
Type protein
Relations 30
Pathways Acute Myeloid Leukemia, ASXL1 in AML, Oxytocin signaling, Retinoic acid Signaling
Function Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RARA 0.522
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RARA 0.274
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RARA 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RARA 0.58
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RARA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EGFR 0.41
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A1 0.296
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CTNNB1 0.385
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Retinoic acid Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLCO1B3 0.2
Publications: 1
+ up-regulates img/direct-activation.png binding THRA 0.402
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png binding RARA 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling
+ up-regulates activity img/direct-activation.png chemical activation RARA 0.8
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RARA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RARA 0.458
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates activity img/direct-activation.png binding RARA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARA 0.691
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates activity img/direct-activation.png chemical activation RARA 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RARA 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CCNA1 0.247
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARA 0.458
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML
+ up-regulates activity img/direct-activation.png binding THR 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARA 0.611
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THR 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.258
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png binding RXRA 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RARA 0.702
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARA 0.402
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRG 0.647
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRG 0.647
Publications: 1 Organism: Homo Sapiens