+ |
CDK7 | up-regulates
phosphorylation
|
RARA |
0.522 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-49693 |
Ser77 |
EIVPSPPsPPPLPRI |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
9230306 |
However, only the coexpression of cdk7 stimulated ser-77 phosphorylation in vivo and enhanced transactivation by rar alpha, but not by a s77a rar mutant. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TFIIH |
phosphorylation
|
RARA |
0.274 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269332 |
Ser77 |
EIVPSPPsPPPLPRI |
Homo sapiens |
|
pmid |
sentence |
11955452 |
Thus, we demonstrate that the cdk7 kinase of tfiih phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDK7 |
phosphorylation
|
RARA |
0.522 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-116582 |
Ser77 |
EIVPSPPsPPPLPRI |
Homo sapiens |
|
pmid |
sentence |
11955452 |
Thus, we demonstrate that the cdk7 kinase of tfiih phosphorylates the nuclear receptor, then allowing ligand-dependent control of the activation of the hormone-responsive genes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT1 | down-regulates
phosphorylation
|
RARA |
0.58 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252489 |
Ser96 |
FVCQDKSsGYHYGVS |
Homo sapiens |
Lung Cancer Cell |
pmid |
sentence |
16417524 |
We report that akt, which is constitutively activated in nsclc cells, phosphorylates raralpha and inhibits its transactivation. / mutation of ser96 to alanine abrogated the suppressive effect of akt. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT | down-regulates
phosphorylation
|
RARA |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-143721 |
Ser96 |
FVCQDKSsGYHYGVS |
Homo sapiens |
Lung Cancer Cell |
pmid |
sentence |
16417524 |
We report that akt, which is constitutively activated in nsclc cells, phosphorylates raralpha and inhibits its transactivation. / mutation of ser96 to alanine abrogated the suppressive effect of akt. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
+ |
RARA | down-regulates quantity by repression
transcriptional regulation
|
EGFR |
0.41 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-114087 |
|
|
Homo sapiens |
|
pmid |
sentence |
11788593 |
We show that retinoic acid receptor (rar)-selective ligands reduce egfr level and the magnitude and duration of egfr activation in egf-stimulated cells |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia |
+ |
RARA | down-regulates quantity by repression
transcriptional regulation
|
NR4A1 |
0.296 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-76980 |
|
|
Homo sapiens |
|
pmid |
sentence |
10772826 |
Retinoic acid and its receptors repress the expression and transactivation functions of nur77 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RARA | down-regulates
|
CTNNB1 |
0.385 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-73274 |
|
|
Homo sapiens |
|
pmid |
sentence |
10607566 |
We shown that retinoic acid (ra) decreases the activity of the beta-catenin-lef/tcf signaling pathway |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling |
+ |
RARA | up-regulates quantity by expression
transcriptional regulation
|
SLCO1B3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268989 |
|
|
|
|
pmid |
sentence |
15322262 |
Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter. |
|
Publications: |
1 |
+ |
RARA | up-regulates
binding
|
THRA |
0.402 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-133231 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Oxytocin signaling |
+ |
RXRA | up-regulates
binding
|
RARA |
0.706 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-16665 |
|
|
Homo sapiens |
|
pmid |
sentence |
1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling |
+ |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RARA |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258138 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
19058965 |
Tazarotene and its analogue 8 are RAR-β,γ selective acetylenic retinoids, whereas analogue 9 is very active on the three subtypes. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256194 |
|
|
Homo sapiens |
|
pmid |
sentence |
17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
Publications: |
2 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, Retinoic acid Signaling |
+ |
THR | up-regulates
binding
|
RARA |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270313 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ASXL1 | up-regulates activity
binding
|
RARA |
0.458 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255910 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
16606617 |
Therefore, ASXL1, a vertebrate PcG/TrxG protein, may mediate RA-regulated cell growth by modulating RAR activity.Finally, the ASXL1-induced accumulation of acetylated H3 may enhance the RAR-mediated transcriptional activity. In this study, we demonstrate that mammalian ASXL1 interacts with the AF-2 AD core of RAR (and RXR) through a novel, promiscuous NR box (LVMQLL) and enhances transcriptional activity of the receptors in certain cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
+ |
THR | up-regulates activity
binding
|
RARA |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267779 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NCOA1 | up-regulates quantity by expression
transcriptional regulation
|
RARA |
0.691 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255932 |
|
|
Homo sapiens |
|
pmid |
sentence |
16606617 |
We also show that ASXL1 associates specifically with SRC-1 and cooperates synergistically in the transcriptional activation. Further data indicated that the transactivation domain (AD; amino acids 300–655) of ASXL1, newly defined in this study, interacts with the C-terminal AD2 (amino acids 1217–1441) of SRC-1, suggesting that one AD cooperates with the other AD in transcriptional activation by RAR. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
+ |
9-cis-retinoic acid | up-regulates activity
chemical activation
|
RARA |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259234 |
|
|
Homo sapiens |
|
pmid |
sentence |
18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KMT2E | up-regulates activity
binding
|
RARA |
0.345 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260041 |
|
|
Homo sapiens |
|
pmid |
sentence |
21205756 |
MLL5 binds to retinoic acid receptor α (RARα) and induces transcriptional activation of RARα target genes by methylation of lysine residues of histone H3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RARA | down-regulates quantity by repression
transcriptional regulation
|
CCNA1 |
0.247 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249636 |
|
|
Homo sapiens |
NB-4 Cell |
pmid |
sentence |
11090075 |
RARα is involved in the regulation of cyclin A1. Further studies using ligands selective for various retinoic acid receptors suggested that cyclin A1 expression is negatively regulated by activated RARα. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
+ |
ASXL1 | up-regulates quantity by expression
transcriptional regulation
|
RARA |
0.458 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255933 |
|
|
Homo sapiens |
|
pmid |
sentence |
16606617 |
We also show that ASXL1 associates specifically with SRC-1 and cooperates synergistically in the transcriptional activation. Further data indicated that the transactivation domain (AD; amino acids 300–655) of ASXL1, newly defined in this study, interacts with the C-terminal AD2 (amino acids 1217–1441) of SRC-1, suggesting that one AD cooperates with the other AD in transcriptional activation by RAR. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
+ |
RARA | up-regulates activity
binding
|
THR |
0.511 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267801 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NCOA2 | up-regulates
binding
|
RARA |
0.611 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-96827 |
|
|
Homo sapiens |
|
pmid |
sentence |
12503607 |
Transcriptional coactivator for steroid receptors and nuclear receptors.nteracts with casp8ap2 and ttll5/stamp. Interacts with esr1, rara and rxra. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RARA | up-regulates
binding
|
THR |
0.511 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270293 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RARA | up-regulates quantity by expression
transcriptional regulation
|
OXT |
0.258 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268548 |
|
|
Homo sapiens |
|
pmid |
sentence |
6153132 |
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Oxytocin signaling |
+ |
RARA | up-regulates
binding
|
RXRA |
0.706 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-16433 |
|
|
Homo sapiens |
|
pmid |
sentence |
1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Retinoic acid Signaling |
+ |
RXRB | up-regulates
binding
|
RARA |
0.702 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-16674 |
|
|
Homo sapiens |
|
pmid |
sentence |
1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
THRA | up-regulates
binding
|
RARA |
0.402 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-133240 |
|
|
Homo sapiens |
|
pmid |
sentence |
15650024 |
We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Oxytocin signaling |
+ |
RARA | up-regulates quantity by expression
transcriptional regulation
|
RXRG |
0.647 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-16469 |
|
|
Homo sapiens |
|
pmid |
sentence |
1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RARA | up-regulates
binding
|
RXRG |
0.647 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-16466 |
|
|
Homo sapiens |
|
pmid |
sentence |
1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
Publications: |
1 |
Organism: |
Homo Sapiens |