Summary

Name NOX4
Full Name NADPH oxidase 4
Synonyms Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase | RENOX
Primary ID Q9NPH5
Links - -
Type protein
Relations 3
Function Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.; FUNCTION

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOX4 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png chemical modification superoxide 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ROS 0.7
Publications: 1 Organism: Homo Sapiens