3.0
Summary
| Name |  NOX4View Modifications |
| Full Name | NADPH oxidase 4 |
| Synonyms | Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase | RENOX |
| Primary ID | Q9NPH5 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.; FUNCTION |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FYN | down-regulates activity 
phosphorylation
|
NOX4 | 0.274 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NOX4 | up-regulates quantity 
chemical modification
|
superoxide | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOX4 | up-regulates
|
ROS | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | E2F1 | up-regulates quantity by expression 
transcriptional regulation
|
NOX4 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |