Summary

Name RRAGD
Full Name Ras-related GTP-binding protein D
Synonyms Rag D, RagD
Primary ID Q9NQL2
Links - -
Type protein
Relations 5
Function Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279).

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Relations

Regulator Mechanism target score ℹ
+ RRAGDform complex img/form-complex.png binding RAGBD 0.766
Publications: 1 Organism: Homo Sapiens
+ RRAGDup-regulates img/direct-activation.png binding mTORC1 0.634
Publications: 1 Organism: Homo Sapiens
+ RRAGDup-regulates img/direct-activation.png binding RPTOR 0.902
Publications: 1 Organism: Homo Sapiens
+ RRAGDform complex img/form-complex.png binding RAGAD 0.762
Publications: 1 Organism: Homo Sapiens
+ FLCNup-regulates activity img/direct-activation.png gtpase-activating protein RRAGD 0.676
Publications: 1 Organism: Homo Sapiens