| + |
ATM | up-regulates activity 
phosphorylation
|
AVEN |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262636 |
Ser135 |
VNNESGEsQRGTDFS |
in vitro |
|
| pmid |
sentence |
| 18571408 |
Aven is also a substrate of the ATM kinase. Mutation of ATM-mediated phosphorylation sites on Aven reduced its ability to activate ATM, suggesting that Aven activation of ATM after DNA damage is enhanced by ATM-mediated Aven phosphorylation. We found that mutating S135 and S308 sites to Alanine largely dampened Aven’s phosphorylation by ATM (though some phosphorylation remained, due to either a contaminating kinase or an unidentified ATM phosphorylation site). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262637 |
Ser308 |
NILPDQTsQDLKSKE |
in vitro |
|
| pmid |
sentence |
| 18571408 |
Aven is also a substrate of the ATM kinase. Mutation of ATM-mediated phosphorylation sites on Aven reduced its ability to activate ATM, suggesting that Aven activation of ATM after DNA damage is enhanced by ATM-mediated Aven phosphorylation. We found that mutating S135 and S308 sites to Alanine largely dampened Aven’s phosphorylation by ATM (though some phosphorylation remained, due to either a contaminating kinase or an unidentified ATM phosphorylation site). |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
AVEN | up-regulates activity
binding
|
ATM |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262638 |
|
|
in vitro |
|
| pmid |
sentence |
| 18571408 |
These data suggest that Aven overexpression can activate ATM and that Aven phosphorylation in a positive feedback loop enforces Aven activity, making it a more potent ATM activator. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
AVEN
- 
- 