| + |
MARK2 | down-regulates activity 
phosphorylation
|
KIF13B |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262955 |
Ser1381 |
KLSRRSIsSPNVNRL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 20194617 |
We report here the identification of GAKIN/KIF13B as a novel in vivo substrate for Par1b and present evidence that GAKIN/KIF13B plays a critical role in axon formation in neurons, which is negatively regulated by Par1b-mediated phosphorylation. Par1b phosphorylates GAKIN/KIF13B at both Ser1381 and Ser1410. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262956 |
Ser1410 |
SNKGRWEsQQDVSQT |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 20194617 |
We report here the identification of GAKIN/KIF13B as a novel in vivo substrate for Par1b and present evidence that GAKIN/KIF13B plays a critical role in axon formation in neurons, which is negatively regulated by Par1b-mediated phosphorylation. Par1b phosphorylates GAKIN/KIF13B at both Ser1381 and Ser1410. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
CDK5 | down-regulates activity
phosphorylation
|
KIF13B |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262737 |
Thr506 |
SEGQVMLtPQKNTRT |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 27512725 |
Overexpression of Cdk5 or its activator p35 promoted and inhibition of Cdk5 activity prevented the KIF13B-TRPV1 association, indicating that Cdk5 promotes TRPV1 anterograde transport by mediating the motor-cargo association. Cdk5 phosphorylates KIF13B at Thr-506, a residue located in the FHA domain. T506A mutation reduced the motor-cargo interaction and the cell-permeable TAT-T506 peptide, targeting to the Thr-506, decreased TRPV1 surface localization, demonstrating the essential role of Thr-506 phosphorylation in TRPV1 transport. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
3.0
KIF13B
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