| + |
SEC31B | form complex 
binding
|
COPII vesicle |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265287 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 30605680 |
The Core Components of COPII Vesicles from HeLa Cells|Membrane-bound Sar1 then recruits the inner COPII coat subcomplex, the Sec23/24 heterodimer. Subsequently, together with cargo proteins recruited by the Sec24 subunit, Sar1 and Sec23/24 assemble into so-called pre-budding complexes. Finally, outer coat subcomplexes, comprising heterotetrameric Sec13/31 complexes, are recruited onto pre-budding complexes to complete the two-layered COPII coat |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 3-RBX1-Skp1 | up-regulates activity 
monoubiquitination
|
SEC31B |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272015 |
|
lys641 |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272016 |
|
lys1176 |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KLHL12 | up-regulates activity
binding
|
SEC31B |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272014 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SEC31B
- 
- 